01 - Our Mission
Breakthrough medecine by personalization.
The goal of The University Hospital Federation APOLLO is to provide a personalized therapeutic response to the main causes of human mortality in the world, namely cardiovascular, pulmonary and chronic renal diseases, as well as to the phenomenon of rejection in solid organ transplants.
Every day we increase human knowledge of the processes of fibrosis, inflammation and remodeling, which are the three main origins of these diseases.
February 24, 2023
Plenary meeting of the FHU APOLLO 2023!
We are pleased to inform you that the next plenary meeting of the FHU APOLLO will take place on March 2, 2023 from 4:00 pm to 6:00 pm, in the premises of the hospital Bîchat-Claude Bernard APHP (amphitheatre CHIRAY) . During this meeting, some of our doctors and researchers will present their latest research and discuss current and future collaborations. We hope you will be able to join us for this important occasion. We are confident that you will appreciate the wealth of information shared at this meeting. We thank you for your continued support.
November 18, 2022
The FHU APOLLO is mobilizing for the 6th wave of calls for RHU projects !
Message from the Director of Research, Innovation, Coordination of the Medical Project and Cooperation AP-HP Nord — Université Paris Cité to DMU executives, members of the GHU research commission and members of the GHU COMEX
August 26, 2022
Join us for Professor Zeevi’s talk the risk of solid organ allograft rejection, this September 7, 2022 at Saint-Louis Hospital.
We are honored and privileged to invite you to our next conference on September 7, 2022 from 3:30 to 5:00 pm in the MILIAN amphitheater of the Saint-Louis Hospital, on the theme : Prognostic tools to assess the risk of solid organ allograft rejection: HLA molecular mismatch, HLA and non-HLA antibodies. A trans organ view; and presented by the eminent Professor : Adriana Zeevi PhD (D) ABHI Distinguished Service Professor of Pathology University of Pittsburgh Medical School Professor of Pathology, Surgery and Immunology Director of Histocompatibility Laboratory We are at your disposal for any further information regarding this symposium. We are confident that your contribution will be very beneficial and look forward to see you !
May 13, 2022
Deployment and development of the Precision Pathology Platform of the Paris Transplant Group
The Paris Transplant Group (PTG) Precision Pathology Platform specializes in RNA/DNA extraction from all types of samples (FFPE, frozen tissues, plasma, etc….) and its analysis (transcriptomic or genomic) using various tools such as the NanoString® nCounter™ or, more recently, the CareDx® AlloSeq™ assay detecting the presence of circulating donor-derived DNA (dd-cfDNA).
02 - Our Approach
APOLLO, an engine of discovery.
By 2030, cardiovascular disease and chronic lung disease will be the two leading causes of death worldwide and, together with chronic kidney disease, they represent a major threat to the global human health care system.
These diseases share important pathophysiological processes, as they all involve fibrosis, inflammation and chronic remodeling that progressively alter the structure of native or transplanted organs, impairing their function, leading to acute and then chronic failure and ultimately death.
Therefore, scientific findings on fibrosis, inflammation and remodeling are major targets for new preventive and curative therapeutic strategies.
02 - Our Approach
Our Research Strategy
02 - Our Approach
APOLLO proposes an integrative assessment combining standard of care, molecular medicine, functional imaging and health information technologies to provide a precision monitoring and diagnostic system applied to patients with chronic cardiovascular, respiratory and renal diseases and to solid organ transplant patients.
With a consortium of 26 clinical partners (APHP), 18 research partners (INSERM, University of Paris) and pharmaceutical companies, APOLLO has a broad reach and will make major contributions to all levels of outcomes in chronic cardiovascular, respiratory, renal and organ transplantation diseases.
APOLLO will not only have a direct impact on patient care, but also has the ambition to transform the entire value chain of chronic disease management; improving the future of research, the future of care delivery, the future of precision medicine, the future of patients and medical education.
03 - Our Missions
The 5 missions of APOLLO
Mission WP1, Fight Fibrosis.
1 - Dissect the link between inflammation and fibrosis.
2 - Decipher the genetic basis of extracellular matrix remodeling and fibrosis.
3 - Identify biomarkers and develop clinical trials in the field of tissue remodeling and fibrosis.
Mission WP2, Multi-physics imaging for diagnosis.
1 - Multi-physics imaging for early detection and staging of fibrosis and inflammation.
2 - Integration of multi-physics imaging with molecular and conventional diagnostics.
Mission WP3, Assessment of immune and non-immune factors in the overall atherosclerotic disease process.
1 - Develop innovative epidemiological approaches that can have a greater impact in cardiovascular and renal prevention.
2 - Demonstrate that circulating PCSK9 concentrations can predict the occurrence of cardiovascular events in high-risk populations.
3 - To study the long-term impact of treatment of chronic inflammatory oral infections on atherosclerotic plaque activity in myocardial infarction survivors.
4 - To establish the prevalence of sleep-disordered breathing in clinical populations with an acute cardiovascular event.
Mission WP4, From inflammation to fibrosis in solid organ transplants.
1 - Building the largest multi-organ transplant cohort in Europe with prospective and standardized data and collection of blood and tissue samples: The Paris-North transplant cohort.
2 - Elucidate the molecular architecture of chronic inflammation in the heart, lung and kidney based on gene expression analysis of grafts and understand the underlying mechanisms of inflammation-induced fibrogenesis.
3 - Provide precision diagnostic algorithms by generating equations derived from biomarkers and gene sets/classifiers that accurately classify the cause, activity and stage of disease in inflammation and fibrosis in solid organ transplants.
Mission WP5, APOLLO Digital Hub: from research to patients.
1 - Building APOLLO-hom-ics: The data infrastructure will integrate the APOLLO cohorts provided by WP1, WP2, WP3 and WP4 and the data generated by the APOLLO platforms.
2 - Digital platform to inform and prepare patients for hospitalization and to connect hospital and ambulatory.
3 - Evaluation of use cases and transformations of self-representation from the patient and caregiver perspective will address adherence, compliance and acceptability of connected care, as part of the Person in Medicine program.
APOLLO Research Strategy
04 - Our Science
APOLLO project has a broad scope and will make major contributions at all levels of cardiovascular, respiratory, renal chronic disease and organ transplant outcomes.
This will not only impact directly on the patients’ care, but has the ambition to transform the entire value chain in chronic disease management.
April 06, 2022
Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study
Beyond associations with similar factors to those reported on extracorporeal membrane oxygenation (EMCO) for non-COVID-19 severe acute respiratory distress syndrome, 90-day survival among ECMO-assisted patients with COVID-19 was strongly associated with a centre's experience in venovenous ECMO during the previous year.
April 06, 2022
Relevant Biomarkers in Medical Practices: An Analysis of the Needs Addressed by an International Survey
The main objective of this study was to collect responses from an international panel of physicians on their needs for biomarkers and also to convey the improvement in the outcome to be made possible by the potential development of fast diagnostic tests for these biomarkers.
April 06, 2022
Accuracy of Smart Scales on Weight and Body Composition: Observational Study
Smart scales are not accurate for body composition and should not replace DEXA in patient care.